Reference Report

Reference
Citation	Azpiazu, N., Frasch, M. (1993). tinman and bagpipe: two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7(7B): 1325--1340. (Export to RIS)
FlyBase ID	FBrf0058519
Publication Type	Research paper
PubMed ID	8101173
PubMed Abstract	Whereas the mechanisms of early Drosophila mesoderm formation have been studied in much detail, the subsequent processes determining regional identities within the mesoderm remain largely unknown. Here, we describe two homeo box genes, tinman (tin) and bagpipe (bap), which spatially subdivide the mesoderm and determine cell fates in the dorsal mesoderm. These two genes are components of a cascade of genetic interactions that result in the spatial restriction of tin mRNA to the dorsal mesoderm and in the activation of bap in segmental clusters of cells in this region. A subset of cells from those clusters segregate to form visceral mesoderm that differentiates into gut musculature. This indicates that the visceral mesoderm is derived from metamerically repeated primordia. In embryos mutant for bap, visceral mesoderm formation is strongly disrupted. Most cells of the visceral mesoderm fail to differentiate properly, and a portion of them are transformed into body wall musculature and gonadal mesoderm. In tin mutant embryos, bap expression is not activated in the dorsal mesoderm. Probably as a consequence, neither visceral mesoderm nor midgut musculature are formed in these mutants, and the absence of visceral mesoderm results in strong disruptions of endoderm migration and midgut morphogenesis. In addition to visceral mesoderm development, tin is required for the formation of the heart from dorsal mesoderm and for the specification of founder cells for particular body wall muscles.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (2)
	Df(3R)e-D7 Df(3R)GC14
Alleles (15)
	bap²⁰⁸ bap^+t11 Ecol\lacZ^A176.1M2 Ecol\lacZ^bap.4.5 Ecol\lacZ^{rols-A490.2M3} Ecol\lacZ^svp-E2-3-9 tin⁴⁵ tin¹⁴² tin^142Δ15 tin^142Δ32 tin²¹² tin²⁹⁴ tin³⁰⁵ tin³⁴⁶ tin^+t10.7
Constructs (3)
	P{bap-lacZ.4.5} P{CaSperRe3} P{CaSperRe28}
Genes (4)
	bap Ecol\lacZ eve tin
Insertions (4)
	P{lacW}svp^E2-3-9 P{lacW}tin¹⁴² P{lArB}A176.1M2 P{lArB}rols^A490.2M3