Reference Report

Reference
Citation	Pongs, O., Lindemeier, J., Zhu, X.R., Theil, T., Engelkamp, D., Krah-Jentgens, I., Lambrecht, H.G., Koch, K.W., Schwemer, J., Rivosecchi, R., Mallart, A., Galceran, J., Canal, I., Barbas, J.A., Ferrus, A. (1993). Frequenin - a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system. Neuron 11(1): 15--28. (Export to RIS)
FlyBase ID	FBrf0059172
Publication Type	Research paper
PubMed ID	8101711
PubMed Abstract	The T(X;Y)V7 rearrangement in Drosophila has originally been recognized as a Shaker-like mutant because of its behavioral and electrophysiological phenotype. The gene whose expression is altered by the V7 rearrangement has been characterized. It encodes a novel Ca(2+)-binding protein named frequenin, which is related to recoverin and visinin. In vitro, the frequenin protein functions like recoverin as a Ca(2+)-sensitive guanylyl cyclase activator. Anti-frequenin antibodies stain the central and peripheral nervous system in Drosophila embryos and in larval and adult tissue sections. Frequenin appears to be particularly enriched in synapses, such as the motor nerve endings at neuromuscular junctions. Neuromuscular junctions of transgenic flies, which overexpress frequenin upon heat shock, exhibit an extraordinarily enhanced, frequency-dependent facilitation of neurotransmitter release, with properties identical to those observed in V7 junctions. We propose that frequenin represents a new element for the Ca(2+)-dependent modulation of synaptic efficacy.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (4)
	T(1;Y)V7 T(1;Y)V29 T(1;Y)W32 Ts(1Lt;YLt)V7
Alleles (3)
	Frq1^hs.PP Frq2^V7 w^+mW.hs
Constructs (1)
	P{TFrq}
Genes (4)
	Frq1 Frq2 mnb w