Reference Report

Reference
Citation	Britt, S.G., Feiler, R., Kirschfeld, K., Zuker, C.S. (1993). Spectral tuning of rhodopsin and metarhodopsin in vivo. Neuron 11(1): 29--39. (Export to RIS)
FlyBase ID	FBrf0059173
Publication Type	Research paper
PubMed ID	8338666
PubMed Abstract	Color vision is dependent upon the expression of spectrally distinct forms of rhodopsin in different photoreceptor cells. To identify the structural features of rhodopsin that regulate spectral sensitivity and absorption in vivo, we have constructed a series of chimeric Drosophila rhodopsin molecules, derived from a blue- and a violet-sensitive rhodopsin, and used P element-mediated germline transformation to generate transgenic flies that express the modified pigments in the R1-R6 photoreceptor cells of the compound eye. Our analysis of these animals indicates that multiple regions of the opsin protein are involved in regulating rhodopsin spectral sensitivity and that the native and photoactivated forms of rhodopsin can be tuned independently of each other. These results demonstrate the feasibility of designing receptor molecules with specifically modified activated states.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (15)
	ninaE::Rh2^Rh1TMD1-7 ninaE::Rh2^Rh1TMD1 ninaE::Rh2^Rh1TMD2-7 ninaE::Rh2^Rh1TMD2 ninaE::Rh2^Rh1TMD3-7 ninaE::Rh2^Rh1TMD3 ninaE::Rh2^Rh1TMD4-7 ninaE::Rh2^Rh1TMD4 ninaE::Rh2^Rh1TMD5-7 ninaE::Rh2^Rh1TMD5 ninaE::Rh2^Rh1TMD6-7 ninaE::Rh2^Rh1TMD6 ninaE::Rh2^Rh1TMD7 ninaE::Rh2^Rh2TMD2 ninaE¹⁷
Constructs (14)
	P{Rh1TM4-7D} P{Rh1TMD1-7} P{Rh1TMD1} P{Rh1TMD2-7} P{Rh1TMD2} P{Rh1TMD3-7} P{Rh1TMD3} P{Rh1TMD4} P{Rh1TMD5-7} P{Rh1TMD5} P{Rh1TMD6-} P{Rh1TMD6} P{Rh1TMD7} P{Rh2TMD2}
Genes (5)
	ninaE ninaE::Rh2 Rh2 Rh3 Rh4