Reference Report

Reference
Citation	Steinemann, M., Steinemann, S., Lottspeich, F. (1993). How Y chromosomes become genetically inert. Proc. Natl. Acad. Sci. U.S.A. 90(12): 5737--5741. (Export to RIS)
FlyBase ID	FBrf0059273
Publication Type	Research paper
PubMed ID	8390679
PubMed Abstract	We have investigated the mechanistic aspects of inactivation of the major larval cuticle protein genes (Lcp1-4) in Drosophila miranda during Y chromosome evolution. The Lcp genes are located on the X2 and neo-Y chromosomes in D. miranda but are autosomally inherited in all other Drosophila species investigated so far. In the neo-Y chromosome all four Lcp loci are embedded within a dense cluster of transposable elements. The X2 Lcp1-4 loci are expressed, while the Y chromosomal Lcp3 locus shows only reduced activity and the Lcp1, Lcp2, and Lcp4 are completely inactive. Our results suggest that Lcp1 and Lcp3 loci on the degenerating Y chromosome of D. miranda are silenced by neighboring transposable elements. These observations support our assumption that the first step in Y chromosome degeneration is the successive silencing of Y chromosomal loci caused by trapping and accumulation of transposons.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (11)
	Dmir\Lcp1Ψ^tY1A Dmir\Lcp1Ψ^tY1B Dmir\Lcp2^tX2 Dmir\Lcp2Ψ^tY2A Dmir\Lcp3^tX3 Dmir\Lcp3Ψ^tY3A Dmir\Lcp3Ψ^tY3B Dpse\Lcp1^tP1 Dpse\Lcp2^tP2 Dpse\Lcp3^tP3 w^+mC
Constructs (10)
	P{H1(Y1A;X2/3)} P{H2(Y1B;X2/3)} P{H3(P1;X2/3)} P{LP2/3} P{LX2/3} P{LY1A} P{LY1B} P{LY2A} P{LY3A} P{LY3B}
Genes (25)
	Dmir\Lcp1 Dmir\Lcp1Ψ Dmir\Lcp2 Dmir\Lcp2Ψ Dmir\Lcp3 Dmir\Lcp3Ψ Dmir\Lcp4 Dmir\Lcp4Ψ Dmir\Lcp5 Dmir\Lcp5Ψ Dmir\Lcp6 Dmir\Lcp6Ψ Dpse\Lcp1 Dpse\Lcp2 Dpse\Lcp3 Dpse\Lcp4 Dpse\Lcp5 Dpse\Lcp6 Lcp1 Lcp2 Lcp3 Lcp4 Lcp65Ab1 Lcp65Ab2 w