Reference Report

Reference
Citation	Mlodzik, M., Baker, N.E., Rubin, G.M. (1990). Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev. 4(11): 1848--1861. (Export to RIS)
FlyBase ID	FBrf0063710
Publication Type	Research paper
PubMed ID	2125959
PubMed Abstract	Mutations in the Drosophila scabrous (sca) gene affect eye and bristle development, leading to irregular spacing of ommatidia and bristle duplications in the adult fly. We have cloned the sca gene by P-element tagging. The sca transcription unit is 12 kb and consists of four exons that are joined in a 3.2-kb mRNA. In an enhancer trap screen we have isolated several P[lacZ] insertions close to the sca transcription start site. We have examined the expression pattern of sca by in situ hybridization to sca transcripts, by beta-galactosidase localization in the P[lacZ] lines, and by immunocytochemistry with an anti-sca antiserum. During embryogenesis, sca is expressed in a dynamic pattern associated with neural development. During imaginal development, sca is mainly expressed in the R8 photoreceptor precursor cells in the eye imaginal disc and in sensory organ precursor cells in other discs. In the wing disc, sca expression is coextensive with the anlagen for bristles and is controlled by genes of the achaete-scute complex. Based on its loss-of-function phenotype, expression pattern, and the predicted structure of its product, a secreted peptide with homology to the fibrinogen gene family, we propose that sca encodes a signal involved in lateral inhibition within individual domains of the developing nervous system.
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Secondary IDs	FBrf0051838
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (2)
	Df(2R)sca-KX2 In(2R)sca^BX1
Alleles (25)
	ac^Hw-1 ac^Hw-49c Ecol\lacZ^sca-2-68 Ecol\lacZ^sca-A2-6 Ecol\lacZ^sca-D120 N^spl-1 sca¹ sca^B1 sca^BP1+RB1 sca^BP1+RB2 sca^BP1 sca^BP2 sca^BP3 sca^BX1 sca^KE3 sca^KE15 sca^KE17 sca^KE305 sca^KX2 sca^OB7 sca^TM4 sca^UM2 sca^WB1 sca^XL1 Su(spl)^KE7
Genes (6)
	ac Ecol\lacZ N pie sca Su(spl)
Insertions (4)
	P{}sca^BP1 P{lacW}2-68 P{lacW}sca^A2-6 P{lacW}sca^D120
Transcripts (1)
	sca-RA