Reference Report

Reference
Citation	Heberlein, U., Hariharan, I.K., Rubin, G.M. (1993). Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev. Biol. 160(1): 51--63. (Export to RIS)
FlyBase ID	FBrf0064497
Publication Type	Research paper
PubMed ID	8224548
PubMed Abstract	The photoreceptor cells R8, R2, and R5 are the first cells to initiate neuronal differentiation in the Drosophila eye imaginal disc. We have shown previously that these three cells require Star gene function for proper ommatidial assembly. Due to the embryonic lethality associated with mutations in Star, we have analyzed the consequence of loss of Star function in mosaic eye imaginal discs. Presumptive R8, R2, and R5 cells that lack Star function fail to differentiate neuronally and die a few hours later. Enhancer trap insertions reveal that Star expression in the eye disc is restricted to the developing R8, R2, and R5 cells. Taken together, these data suggest that Star is required for the reception of a signal and/or the execution of a developmental program that leads to the neuronal differentiation of R8, R2, and R5. Star is also required for the formation of wing veins and is expressed in developing veins, suggesting that at least partially overlapping pathways may operate during photoreceptor cell differentiation and wing vein formation. The role of Star in cell-cell signaling is supported by the observation of genetic interactions between Star and mutations that reduce signaling through both sevenless and the Drosophila EGF-receptor homologue, including Ras1 and Son of sevenless.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (16)
	Ecol\lacZ^S-05671 Ecol\lacZ^S-7051 Ecol\lacZ^S-rK134 Egfr^E1 Ras85D^e1B Ras85D^e2F S¹²⁶ S²¹⁸ S⁰⁵⁶⁷¹ S⁷⁰⁵¹ S^rK134 S^X155 Scer\FLP1^hs.PG Sos^e4G Sos^e6C Sos^x15
Constructs (1)
	P{hsFLP}
Genes (8)
	Ecol\lacZ Egfr elav Ras85D S Scer\FLP1 sev Sos
Insertions (4)
	P{}S¹²⁶ P{lacZ}S⁷⁰⁵¹ P{PZ}S⁰⁵⁶⁷¹ P{PZ}S^rK134