Reference Report

Reference
Citation	Hecht, P.M., Anderson, K.V. (1993). Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics 135(2): 405--417. (Export to RIS)
FlyBase ID	FBrf0064499
Publication Type	Research paper
PubMed ID	8244004
PubMed Abstract	tube and pelle are two of the maternally transcribed genes required for dorsal-ventral patterning of the Drosophila embryo. Females homozygous for strong alleles of tube or pelle produce embryos that lack all ventral and lateral embryonic pattern elements. By analyzing the phenotypes caused by 24 pelle and 9 tube alleles, we have defined characteristic features of the two genes, including the extremely variable phenotypes of a number of tube alleles and the antimorphic character of a number of pelle alleles. Double mutant females carrying dominant ventralizing alleles of Toll and dorsalizing alleles of tube or pelle produce dorsalized embryos, suggesting that tube and pelle act downstream of the membrane protein Toll in the signaling pathway that defines the embryonic dorsal-ventral pattern. Both tube and pelle are also important zygotically for survival: at least 30% of the zygotes lacking either tube or pelle die before adult stages, while 90-95% of tube- pelle- double mutant zygotes die. We discuss the phenotypes of tube-pelle double mutants in the context of whether the two proteins interact directly.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	Df(3R)D605 Df(3R)R38.3 Df(3R)XM3
Alleles (42)
	pll¹ pll² pll³ pll⁴ pll⁵ pll⁷ pll⁸ pll⁹ pll¹⁰ pll^10P pll^11H pll¹² pll¹³ pll¹⁴ pll¹⁵ pll¹⁶ pll¹⁷ pll¹⁸ pll²⁰ pll²¹ pll²² pll²³ pll²⁴ pll²⁵ pll¹¹⁸ pll²³⁸ Tl¹ Tl³ Tl^3p Tl^3t Tl⁸ Tl^rv22 tub¹ tub² tub³ tub⁴ tub⁵ tub⁶ tub⁷ tub⁸ tub⁹ tub^R5.6
Genes (4)
	pll spz Tl tub
Insertions (3)
	P{}Tl^rv22 P{}tub⁹ P{S38M}7