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Reference
Citation
Biggs, W.H., Zavitz, K.H., Dickson, B., van der Straten, A., Brunner, D., Hafen, E., Zipursky, S.L. (1994). The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.  EMBO J. 13(7): 1628--1635.
FlyBase ID
FBrf0068416
Publication Type
Research paper
Abstract

Mitogen-activated protein (MAP) kinases have been proposed to play a critical role in receptor tyrosine kinase (RTK)-mediated signal transduction pathways. Although genetic and biochemical studies of RTK pathways in Caenorhabditis elegans, Drosophila melanogaster and mammals have revealed remarkable similarities, a genetic requirement for MAP kinases in RTK signaling has not been established. During retinal development in Drosophila, the sevenless (Sev) RTK is required for development of the R7 photoreceptor cell. Components of the signal transduction pathway activated by Sev in the R7 precursor include proteins encoded by the gap1, drk, Sos, ras1 and raf loci. In this report we present evidence that a Drosophila MAP kinase, ERK-A, is encoded by the rolled locus and is required downstream of raf in the Sev signal transduction pathway.

PubMed ID
PubMed Central ID
PMC394993 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (1)
    Alleles (16)
    Gene Groups (1)
    Genes (8)
    Transgenic Constructs (3)