Reference Report

Reference
Citation	Brunner, D., Oellers, N., Szabad, J., Biggs, W.H., Zipursky, S.L., Hafen, E. (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76(5): 875--888. (Export to RIS)
FlyBase ID	FBrf0068431
Publication Type	Research paper
PubMed ID	8124723
PubMed Abstract	In the Drosophila eye, activation of the sevenless (sev) receptor tyrosine kinase is required for the specification of the R7 photoreceptor cell fate. In a genetic screen for mutations that result in the activation of the sev signaling pathway in the absence of the inducing signal, we identified a gain-of-function mutation in rolled (rlSevenmaker [rlSem]), which encodes a homolog of mitogen-activated protein (MAP) kinase. In addition to the sev pathway, this mutation activates the pathways controlled by torso and the epidermal growth factor receptor homology. The rlSem mutation results in the substitution of a single conserved amino acid in the kinase domain. Activation of MAP kinase by the rlSem mutation is both necessary and sufficient to activate multiple signaling pathways controlled by receptor tyrosine kinases.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2R)rl10a
Alleles (24)
	boss³⁹⁹¹ Ecol\lacZ^Kr.amn Ecol\lacZ^Rh3.P Egfr^E1 Egfr^E3 Egfr^f11 Egfr^t1 ort¹ phl::tor^12D.hs.sev phl¹ phl¹² phl¹⁰⁷ Ras85D^V12.sev rl¹ rl¹⁰ rl^D334N.hs.sev rl^hs.sev rl^{K67M:D334N.hs.sev} rl^Sem rl^SemR44 sev¹⁴ sina^unspecified tll¹ tor^11D
Constructs (7)
	P{Kr-lacZ.B} P{Rh3-β-gal} P{sE-raf^torY9} P{sE-rl⁺} P{sE-rl^D334N} P{sE-rl^K67M/D334N} P{sevRas1.V12}
Genes (12)
	boss Ecol\lacZ Egfr ort phl phl::tor Ras85D rl sev sina tll tor