Reference Report

Reference
Citation	Hart, K., Klein, T., Wilcox, M. (1993). A Minute encoding a ribosomal protein enhances wing morphogenesis mutants. Mech. Dev. 43(2-3): 101--110. (Export to RIS)
FlyBase ID	FBrf0068519
Publication Type	Research paper
External Crossreferences
PubMed ID	8297785
PubMed Abstract	E(Dl)KP135 has been isolated previously as a recessive lethal Drosophila P element insertion line with a dominant enhancing effect on the phenotype of Delta, a gene encoding a surface membrane protein. We show here that this P insertion also enhances the wing phenotype of nd1, an allele of Notch encoding another transmembrane protein, the putative receptor of Delta, as well as that of if3, an allele of the integrin gene PS2 alpha. Moreover, we noticed that this P insertion causes a severe Minute phenotype. Molecular characterisation revealed that the P element disrupts the putative mRNA leader sequence of the ribosomal protein L19 gene. We tested further Minute genes and found that two of them, similarly to E(Dl)KP135, strongly enhance the nd1 wing phenotype. Our results suggest that the pleiotropic Minute syndrome can affect, probably indirectly, one or more steps of wing morphogenesis that involve surface adhesion of epithelial cells.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Editors
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (5)
	Df(2R)Dll-MP Df(2R)ES1 Df(2R)gsb Df(2R)M60E Df(3R)M86D
Alleles (12)
	if³ M(2)53^unspecified M(2)201¹ N^nd-1 RpL19^ex1 RpL19^ex16 RpL19^ex31 RpL19^ex34 RpL19^ex51 RpL19^P RpS5a² RpS17⁴
Genes (9)
	emp if M(2)53 M(2)201 N RpL19 RpS5a RpS17 RpS25
Insertions (4)
	P{?lacW}RpL19^ex1 P{?lacW}RpL19^ex16 P{?lacW}RpL19^ex51 P{lacW}RpL19^P