Reference Report

Reference
Citation	Nurminsky, D.I. (1993). Two subfamilies of MDG1 retrotransposon with different evolutionary histories in D. melanogaster. J. Mol. Evol. 37(5): 496--503. (Export to RIS)
FlyBase ID	FBrf0068611
Publication Type	Research paper
PubMed ID	8283481
PubMed Abstract	Two copies of nonmobile retrotransposon localized in D. melanogaster heterochromatin (mdg1het) were sequenced at the 3'-end. The comparison of 2.5-kb mdg1het sequences with the sequence of cognate euchomatic transposable copies (mdg1tr) revealed an intact mdg1 ORF2 encoding the pol gene in mdg1het, and two-thirds of nucleotide substitutions in this ORF were synonymous. All the known mdg1 regulatory elements in the mdg1het LTR also are conserved, in spite of numerous deletions and nucleotide substitutions elsewhere in this region. These data suggest that the mdg1het subfamily lost its mobility more recently than other functions were lost. The G-->A hypermutation known to occur in the reverse transcription cycle of retroviruses was detected in one mdg1het copy. The structure of the enchancer-like region in mdg1het suggests a reduced transcription level and, therefore, transposition frequency, relative to mdg1tr. The number of nucleotide substitutions suggests that the time of mdg1het mobility loss was less than 0.3-0.5 Myr ago.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Mol. Evol.
Title	Journal of Molecular Evolution
Publication Year	1971-
ISBN/ISSN	0022-2844
Data from Reference
Natural transposons (1)
	mdg1