Reference Report

Reference
Citation	DiAntonio, A., Schwarz, T.L. (1994). The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron 12(4): 909--920. (Export to RIS)
FlyBase ID	FBrf0072958
Publication Type	Research paper
PubMed ID	7909234
PubMed Abstract	Synaptotagmin is a synaptic vesicle protein implicated in neurotransmitter release. Molecular characterization of four mutant alleles of this protein in Drosophila melanogaster has permitted an investigation of synaptotagmin's role in synaptic physiology and of some of the structural requirements for its function. Reduced levels of synaptotagmin resulted in a substantial alteration in synaptic function in the eye and at larval neuromuscular junctions. Decreased neurotransmitter release caused smaller evoked synaptic potentials. However, the frequency, but not the size, of spontaneous quantal events was simultaneously increased. These abnormalities do not appear to be secondary to a detectable morphological change in the arborization of the synapse. The increased frequency of spontaneous events was insufficient to deplete significantly the vesicle supply and thereby account for reduced transmission. These data are discussed in the context of models in which synaptotagmin's function includes a role in vesicle docking.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (3)
	Df(2L)DTD2 In(2)syt^D27 Tp(2;1)DTD2
Alleles (5)
	Syt1^AD1 Syt1^AD3 Syt1^AD4 Syt1^D27 Syt1^elav.PD
Constructs (1)
	P{elav-syt}
Genes (1)
	Syt1