Reference Report

Reference
Citation	Diaz-Benjumea, F.J., Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120(3): 569--578. (Export to RIS)
FlyBase ID	FBrf0072959
Publication Type	Research paper
PubMed ID	8162856
PubMed Abstract	In Drosophila, Drk, an SH2 adaptor protein, Sos, a putative activator of Ras1, Ras1, raf and rolled/MAP kinase have been shown to be required for signalling from the sevenless and the torso receptor tyrosine kinase. From these studies, it was unclear whether these components act in a single linear pathway as suggested by the genetic analysis or whether different components serve to integrate different signals. We have analyzed the effects of removing each of these components during the development of the adult epidermal structures by generating clones of homozygous mutant cells in a heterozygous background. Mutations in each of these signalling components produce a very similar set of phenotypes. These phenotypes resemble those caused by loss-of-function mutations in the Drosophila EGF receptor homolog (DER). It appears that these components form a signalling cassette, which mediates all aspects of DER signalling but that is not required for other signalling processes during epidermal development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2R)rl10a
Alleles (18)
	Dl^M1 drk^R1 Egfr^E3 Egfr^f37 Egfr^t1 f^+t13 N^55e11 phl¹ phl⁷ Ras85D^e2F rl¹ rl⁹ rl¹⁰ rl^la8 rl^Sem Sos^34Ea-7 Sos^x122 vvl^M3
Constructs (1)
	P{f⁺13}
Genes (18)
	ci Dl drk Egfr f N net phl px Ras64B Ras85D rho rl S Sos tt Vno vvl