Reference Report

Reference
Citation	Dorer, D.R., Henikoff, S. (1994). Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77(7): 993--1002. (Export to RIS)
FlyBase ID	FBrf0072979
Publication Type	Research paper
PubMed ID	8020105
PubMed Abstract	Closely linked repeats of a Drosophila P transposon carrying a white transgene were found to cause white variegation. Arrays of three or more transgenes produced phenotypes similar to classical heterochromatin-induced position-effect variegation (PEV), and these phenotypes were modified by known modifiers of PEV. This effect on the repeated transgenes was much stronger for a site near centric heterochromatin than it was for a medial site, and it strengthened with increasing copy number. Differences between variegated phenotypes could be accounted for if different topological structures were generated by pairing between closely linked repeat sequences. We propose that pairing of repeats underlies heterochromatin formation and is responsible for diverse gene silencing phenomena in animals and plants.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	T(2;3)V21
Alleles (4)
	Sb¹ Sb^unspecified w¹¹¹⁸ w^+mC
Balancers (2)
	T(2;3)V21-P{lacW}92E.x3 T(2;3)V21-Sb
Constructs (1)
	P{lacW}
Genes (3)
	Sb Su(var)205 w
Insertions (10)
	P{bw⁺L}92C P{lacW}50C P{lacW}50C.x2 P{lacW}50C.x3 P{lacW}50C.x4 P{lacW}50C.x7 P{lacW}92E P{lacW}92E.x2 P{lacW}92E.x3 P{lacW}92E.x4