Reference Report

Reference
Citation	Edgar, B.A., Lehman, D.A., O'Farrell, P.H. (1994). Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development 120(11): 3131--3143. (Export to RIS)
FlyBase ID	FBrf0073015
Publication Type	Research paper
PubMed ID	7720557
PubMed Abstract	During postblastoderm embryogenesis in Drosophila, cell cycles progress in an invariant spatiotemporal pattern. Most of these cycles are differentially timed by bursts of transcription of string (cdc25), a gene encoding a phosphatase that triggers mitosis by activating the Cdc2 kinase. An analysis of string expression in 36 pattern-formation mutants shows that known patterning genes act locally to influence string transcription. Embryonic expression of string gene fragments shows that the complete pattern of string transcription requires extensive cis-acting regulatory sequences (> 15.3 kb), but that smaller segments of this regulatory region can drive proper temporal expression in defined spatial domains. We infer that string upstream sequences integrate many local signals to direct string's transcriptional program. Finally, we show that the spatiotemporal progression of string transcription is largely unaffected in mutant embryos specifically arrested in G2 of cycles 14, 15, or 16, or G1 of cycle 17. Thus, there is a regulatory hierarchy in which developmental inputs, not cell cycle inputs, control the timing of string transcription and hence cell cycle progression.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (8)
	Df(1)N-8 Df(1)sc-B57 Df(2L)TE35D-1 Df(2L)TE35D-3 Df(2R)59AB Df(3R)P9 Df(3R)stg^AR2 Df(3R)tll-e
Alleles (50)
	Antp²⁵ bcd⁶ btd^A1 CycA⁵ CycE^AR95 da¹⁰ Dfd^r dl¹ dpp^H48 E(spl)m8-HLH^unspecified ems¹ en^CX1 eve¹ fkh¹ ftz^Ual2 gt^13z h²⁶ hb^P25 kni^5H Kr²⁵⁶ neur^KX9 nkd² oc⁹ run²⁸ S⁵⁴ salm¹ Scr^7F sim² sna¹⁸ SP1029^BCDE spi¹ stg² stg¹² stg^AA53 stg^AR1 stg^AR2 stg^AR3 stg^AR4 stg^AR5 stg^AR6 stg^AR7 stg^AR8 stg^BCD stg^BCDE stg^CD stg^unspecified tor^rv66 twi¹ wg^l-17 zen⁷
Constructs (3)
	P{CD} P{stg15.3} P{stg31.3}
Genes (40)
	anon-99A Antp bcd btd CycA CycB CycE da Dfd dl dpp E(spl)m8-HLH ems en eve fkh ftz gt h hb kni Kr neur nkd oc run S salm sc Scr sim sna SP1029 spi stg tll tor twi wg zen
Insertions (1)
	P{lwB}stg^AA53