Reference Report

Reference
Citation	Nellen, D., Affolter, M., Basler, K. (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78(2): 225--237. (Export to RIS)
FlyBase ID	FBrf0074016
Publication Type	Research paper
PubMed ID	8044837
PubMed Abstract	Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv). Further, we show that mutations that abolish sax or tkv activity cause phenotypes similar to partial or complete loss of activity, respectively, of the TGF beta homolog decapentaplegic (dpp). We propose that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (12)
	Df(2L)cl-h2 Df(2L)cl-h3 Df(2L)sc19-1 Df(2L)sc19-5 Df(2L)tkv3 Df(2R)CA53 Df(2R)cn9 Df(2R)cn83c Df(2R)P32a Df(2R)pk78k Df(2R)pk78s Tp(2;3)tkv
Alleles (12)
	dpp^hr27 dpp^hr56 Ecol\lacZ^Kr.amn sax¹ sax² sax^+t8.9 sax^K291M sax^P sax^unspecified tkv⁴ tkv⁷ tkv⁸
Constructs (2)
	P{sax⁺8.9} P{sax^K291M}
Genes (5)
	dpp Ecol\lacZ lab sax tkv
Insertions (1)
	P{lacW}sax^P