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Citation
Sanchez, L., Granadino, B., Torres, M. (1994). Sex determination in Drosophila melanogaster: X-linked genes involved in the initial step of sex-lethal activation.  Dev. Genet. 15(3): 251--264.
FlyBase ID
FBrf0074350
Publication Type
Research paper
Abstract

Sex determination is the commitment of an embryo to either the female or the male developmental pathway. The ratio of X chromosomes to sets of autosomes is the primary genetic signal that determines sex in Drosophila, by triggering the functional state of the gene Sex-lethal: in females (2X;2A) Sxl will be ON, whereas in males (X;2A) Sxl will be OFF. Genetic and molecular studies have defined a set of genes involved in the formation of the X:A signal, as well as other genes, with either maternal or zygotic effects, which are also involved in regulating the initial step of Sex-lethal activation. We review these data and present new data on two more regions of the X chromosome that define other genes needed for Sxl activation. In addition, we report on the interaction between some of the genes regulating Sxl activation.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Genet.
    Title
    Developmental Genetics
    Publication Year
    1979-1999
    ISBN/ISSN
    0192-253X
    Data From Reference