Reference Report

Reference
Citation	Birchler, J.A., Bhadra, U., Rabinow, L., Linsk, R., Nguyen-Huynh, A.T. (1994). Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. Genetics 137(4): 1057--1070. (Export to RIS)
FlyBase ID	FBrf0074960
Publication Type	Research paper
PubMed ID	7982560
PubMed Abstract	A locus is described in Drosophila melanogaster that modifies the expression of the white eye color gene. This trans-acting modifier reduces the expression of the white gene in the eye, but elevates the expression in other adult tissues. Because of the eye phenotype in which the expression of white is lessened but not eliminated, the newly described locus is called the Weakener of white (Wow). Northern analysis reveals that Wow can exert an inverse or direct modifying effect depending upon the developmental stage. Two related genes, brown and scarlet, that are coordinately expressed with white, are also affected by Wow. In addition, Wow modulates the steady state RNA level of the retrotransposon, copia. When tested with a white promoter-Alcohol dehydrogenase reporter. Wow confers the modifying effect to the reporter, suggesting a requirement of the white regulatory sequences for mediating the response. In addition to being a dosage sensitive regulator of white, brown, scarlet and copia, Wow acts as a suppressor of position effect variegation. There are many dosage sensitive suppressors of position effect variegation and many dosage-sensitive modifiers of gene expression. The Wow mutations provide evidence for an overlap between the two types of modifiers.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (16)
	Df(3L)81k19 Df(3L)in61 Df(3L)kto2 Df(3L)rdgC-co2 Df(3L)ri-79c Df(3L)st-f13 Df(3L)th102 Df(3L)VW3 Df(3L)W4 Df(3L)W10 Dp(1;1)w⁺61e19 Dp(3;Y)L131-D3 In(1)w^m4 In(2L)lt^X2 T(Y;3)L131 Tp(3;Y)L131-D3
Alleles (47)
	lt^X84 w¹ w^+mC w^+mF w^a2 w^a3 w^a4 w^a59k1 w^a w^Adh.PB w^aM w^apl w^aR84h w^bf2 w^bf w^bl w^Bwx w^c w^cf w^co w^col w^DZL w^e w^E w^h wⁱ w^IR1 w^IR2 w^IR3 w^IR4 w^IR5 w^IR6 w^is w^ric w^sat w^sp1 w^sp2 w^sp4 w^sp55 w^sp81d w^zl w^zm Wow^ems1 Wow^hd1 Wow^γb Wow^γe z¹
Genes (12)
	bw kni lt Sb st Su(var)3-3 th w W Wow z βTub56D
Insertions (2)
	coral{}w^co mdg3{}w^sp55
Natural transposons (1)
	copia