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Reference
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| Citation |
Gonzalez-Gaitan, M.A.F., Rothe, M., Wimmer, E.A., Taubert, H., Jaeckle, H. (1994). Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures. Proc. Natl. Acad. Sci. USA 91(18): 8567--8571. |
| FlyBase ID |
FBrf0075001 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
8078924 |
| PubMed Abstract |
Developmental gene functions of Drosophila are typically characterized by a recognizable mutant phenotype. When molecular
probes of such genes were used to isolate homologues, distinct spatially and temporally restricted expression patterns were
observed in vertebrates as well. However, corresponding "gene knock-outs" often revealed subtle or no scorable phenotypes,
a phenomenon attributed to redundant gene functions. We found that the evolutionarily related genes knirps (kni) and knirps-related
(knrl) contribute to a similar phenomenon in Drosophila. The two closely situated genes show identical expression patterns
in the developing embryo, including the posterior and anterior expression domains in the blastoderm. Here we show that the
two biochemically equivalent gene products are both functional in the head anlage and that the lack of one gene activity can
be overcome by the activity of the other. Whereas kni is also required for abdominal segmentation, knrl is nonfunctional in
its posterior expression domain. Thus, the kni/knrl pair of genes provides a region-specific buffering system, rather than
a case of global functional redundancy.
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| Biosis |
97448659 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
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Data from Reference
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| Aberrations (1)
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| Alleles (3)
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| Constructs (1)
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| Genes (2)
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