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Citation
Zeng, H., Hardin, P.E., Rosbash, M. (1994). Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.  EMBO J. 13(15): 3590--3598.
FlyBase ID
FBrf0075095
Publication Type
Research paper
Abstract

The Drosophila period gene (per) is a likely component of a circadian pacemaker. per protein (PER) participates in the regulation of its own expression, at least in part at the transcriptional level. There is at present no direct evidence that the effect of PER on its own transcription is intracellular. Results presented in this paper show that (i) the circadian oscillations of both per mRNA and PER protein are quantitatively similar in eye photoreceptor cells and in brain; (ii) constitutive overexpression of PER only in photoreceptors R1-R6 represses endogenous per RNA cycling in these cells but not in other per-expressing cells; (iii) the overexpression construct has no effect on locomotor activity rhythms. These results indicate that the autoregulation of per expression is a direct, intracellular event and suggest that each per-expressing cell contains an autonomous oscillator of which the per feedback loop is a component.

PubMed ID
PubMed Central ID
PMC395264 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
  • FBrf0074893
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
EMBO J.
Title
The EMBO Journal
Publication Year
1982-
ISBN/ISSN
0261-4189
Data From Reference
Alleles (5)
Genes (3)
Transgenic Constructs (1)