|
Reference
|
| Citation |
Ruden, D.M., Jaeckle, H. (1995). Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm. Development 121(1): 63--73. |
| FlyBase ID |
FBrf0076145 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
|
External Crossreferences
|
| PubMed ID |
7867508 |
| PubMed Abstract |
The Drosophila body pattern is laid down by maternal and zygotic factors which act during the early phase of embryonic development.
During this period, nascent zygotic transcripts longer than about 6 kilobases are aborted between the rapid mitotic cycles.
Resurrector1 (Res1) and Godzilla1 (God1), two newly identified dominant zygotic suppressor mutations, and a heterozygous maternal
deficiency of the cyclin B locus, complement the partial loss of function of the segmentation gene knirps (kni) by extending
the length of mitotic cycles at blastoderm. The mitotic delay caused by Res1 and God1 zygotically and by the deficiency of
the cyclin B locus maternally allows the expression of a much longer transcript of a kni cognate gene normally aborted between
the short mitotic cycles and consequently allows survival of kni mutant progeny. In addition to the practical benefits of
identifying mutations in Drosophila cell cycle regulatory genes as suppressors of kni, our results have evolutionary implications
regarding the flexibility of the genome to meet sudden selective pressures by recruiting cognate genes to function.
|
| Biosis |
98172309 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Development |
| Title |
Development |
| Authors |
|
| Volume range |
99- |
| Year range |
1987- |
| Page range |
|
| Publisher |
|
| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
|
Data from Reference
|
| Aberrations (5)
|
|
|
| Alleles (14)
|
|
|
| Genes (10)
|
|
|
| Insertions (1)
|
|
|
|
Home