Reference Report

Reference
Citation	Arora, K., Levine, M.S., O'Connor, M.B. (1994). The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes Dev. 8(21): 2588--2601. (Export to RIS)
FlyBase ID	FBrf0076510
Publication Type	Research paper
PubMed ID	7958918
PubMed Abstract	The decapentaplegic (dpp) gene product, a TGF-beta related ligand, acts as an extracellular morphogen to establish at least two cellular response thresholds within the dorsal half of the Drosophila embryo. Null mutations in the screw (scw) gene are phenotypically similar to moderate dpp mutants and cause dorsal cells to adopt ventral fates. We show that scw encodes a novel TGF-beta protein and is an integral part of the signal that specifies dorsal pattern. Although scw is expressed uniformly during blastoderm stages, its effect on development appears graded and is restricted to the dorsal side of the embryo. Our results indicate that DPP activity alone is insufficient to specify different dorsal cell fates. We propose that SCW and DPP act together to establish distinct response boundaries within the dorsal half of the embryo, perhaps by forming heterodimers that have higher activity than homodimers of either molecule alone.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (3)
	Df(2L)OD16 Df(2L)pr65 Df(2L)scw-E1r2
Alleles (13)
	anon-38Aa^KA66 dpp^fl.cAa dpp^H48 Ecol\lacZ^Kr.P Ecol\lacZ^wg-en11 Lar^hs.PAa Lar^Hsp83.PAa scw² scw⁴ scw⁵ scw^+t11.7 scw^+t12.6 scw^tld.PA
Constructs (7)
	P{hsp70-dlar} P{hsp83-dlar} P{KA45} P{KA55} P{KA66} P{Kr-lacZ} P{tld-scw}
Genes (6)
	anon-38Aa bsh dpp Ecol\lacZ Lar scw
Insertions (1)
	P{en1}wg^en11