Reference Report

Reference
Citation	Littleton, J.T., Bellen, H.J. (1994). Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila. Genetics 138(1): 111--123.
FlyBase ID	FBrf0076536
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	8001779
PubMed Abstract	In an attempt to identify mutations in the Drosophila synaptotagmin gene we have isolated many new rearrangements, point mutations and P element insertions in the 22F1-2; 23B1-2 cytological interval on chromosome arm 2L. This interval encompasses 13 cytological bands and is shown to contain 13 essential complementation groups, including decapentaplegic, synaptotagmin and Curly. Through chemical and P element mutagenesis we have isolated seven new deletions, which combined with previously isolated rearrangements, have allowed us to order most genes in the interval. A genomic walk covering approximately 100 kb within this interval spans at least five essential genes as identified by chromosomal aberrations. Preliminary phenotypic characterizations of the mutant phenotype and lethal phase is presented for many mutations. Three loci within this interval are shown to be required for proper neural development. Given that the average number of alleles per complementation group is greater than seven, it is very likely that all essential genes within this cytological interval have been identified.
Biosis	97462283
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Language of publication	English
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Abbreviation	Genetics
Title	Genetics
Authors
Volume range	1-
Year range	1916-
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Place of publication	Austin, TX, etc
Language of publication	English
ISBN/ISSN	0016-6731
CODEN	GENTAE
Data from Reference
Aberrations (17)
	Ab(2L;?)34Cy^rv Df(2L)C144 Df(2L)D20 Df(2L)D31 Df(2L)DTD2 Df(2L)N19 Df(2L)N6 Df(2L)TL1 Df(2L)dpp-H34 Df(2L)dpp-H59 Df(2L)dpp^d14 Df(2L)dpp^d19 Df(2L)dpp^d33 Dp(2;2)dpp^d21 In(2L)54Cy^rv Tp(2;1)DTD2 Tp(2;2)dpp^d21
Alleles (102)
	Cy^66.14 Cy^66.5 Cy^67.3 Cy^D12 Cy^D13 Cy^D21 Cy^D25 Cy^T16 Cy^T18 Cy^T25 Cy^T31 Cy^T32 Cy^T37 Cy^T38 Cy^T43 Cy^T51 Cy^T61 Cy^T62 Cy^drv1 Cy^rv11 Cy^rv27 Cy^rv67 Drp1^D20 Drp1^H12 Drp1^H22 Drp1^H30 Drp1^T1 Drp1^T26 Drp1^T9 Ecol\lacZ⁰³⁷²⁸ Ecol\lacZ^B8-2-30 Ecol\lacZ^E10-2-19 Ecol\lacZ^KZ1941 Ecol\lacZ^P\T.T:Khc Ecol\lacZ^P\T.W Ecol\lacZ^syt-T77 Hrs^AD20 Hrs^D28 Pgk^AD11 Pgk^T63 aph-1^AD25 aph-1^D35 dpp^D11 dpp^D36 dpp^D42 dpp^T10 dpp^T14 dpp^T24 dpp^T33 dpp^T39 dpp^T40 dpp^T50 dpp^T65 dpp^T66 dpp^s4 dpp^t63 l(2)03728⁰³⁷²⁸ l(2)23AB2^56.12 l(2)23AB2^AD5 l(2)23AB2^D27 l(2)23AB2^T21 l(2)23AB2^T29 l(2)23AB2^T9 l(2)23AB4^55.1 l(2)23AB4^55.5 l(2)23AB4^AD16 l(2)23AB4^T60 l(2)23AB4^T6 l(2)23Ab^55.6 l(2)23Ab^56.1 l(2)23Ab^58.14 l(2)23Ab^58.2 l(2)23Ab^58.3 l(2)23Ab^D31 l(2)23Ab^N19 l(2)23Ab^T71 nrd^54.6 nrd^77.3 nrd^D20 nrd^D31 nrd^D46 oaf^H39 oaf^T12 oaf^T28 oaf^T3 oaf^T57 oaf^T58 syt^66.4 syt^D2 syt^D37 syt^D39 syt^D3 syt^D45 syt^N10 syt^N13 syt^N19 syt^N28 syt^N6 syt^T11 syt^T41 syt^T77 syt^T7
Genes (16)
	Cy Drp1 Ecol\lacZ Hrs Khc Pgk aph-1 dpp l(2)03728 l(2)23AB2 l(2)23AB4 l(2)23AB7 l(2)23Ab nrd oaf syt
Insertions (8)
	P{3'lacW}syt^N10 P{3'lacW}syt^N28 P{5'lacW}syt^N13 P{KZ.TRAP}KZ1941 P{PZ}03728 P{lacW}B8-2-30 P{lacW}E10-2-19 P{lacW}syt^T77