Reference Report

Reference
Citation	Csink, A.K., Linsk, R., Birchler, J.A. (1994). The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles. Genetics 138(1): 153--163. (Export to RIS)
FlyBase ID	FBrf0076540
Publication Type	Research paper
PubMed ID	8001783
PubMed Abstract	We are interested in identifying single gene mutations that are involved in trans-acting dosage regulation in order to understand further the role of such genes in aneuploid syndromes, various types of dosage compensation as well as in regulatory mechanisms. The Lighten up (Lip) gene in Drosophila melanogaster was identified in a mutagenic screen to detect dominant second site modifiers of white-blood (wbl), a retrotransposon induced allele of the white eye color locus. Lip specifically enhances the phenotype of wbl as well as a subset of other retroelement insertion alleles of white, including the copia-induced allele, white-apricot (wa), and six alleles caused by insertion of I elements. We isolated six alleles of Lip which are all recessive lethal, although phenotypically additive heteroallelic escapers were recovered in some combinations. Lip also suppresses position effect variegation, indicating that it may have a role in chromatin configuration. Additionally, Lip modifies the total transcript abundance of both the blood and copia retrotransposons, having an inverse effect on the steady state level of blood transcripts, while showing a non-additive effect on copia RNA.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	Dp(1;1)w⁺61e19 In(1)w^m4h T(2;3)Sb^V
Alleles (44)
	Rm62^D Rm62^Dem Rm62^E Rm62^F Rm62^H Rm62^K w^a2 w^a3 w^a4 w^a59k1 w^a w^Adh.PB w^aM w^apl w^aR84h w^bf2 w^bf w^bl w^Bwx w^c w^cf w^co w^col w^e w^ec3 w^h wⁱ w^IR1 w^IR2 w^IR3 w^IR4 w^IR5 w^IR6 w^is w^mo w^ric w^sp1 w^sp2 w^sp4 w^sp55 w^sp81d w^t w^zl w^zm
Constructs (1)
	P{Adh-w.B}
Genes (8)
	Rm62 Sb sens Su(var)3-7 Su(var)3-8 Su(var)3-9 Su(var)3-10 w
Insertions (13)
	?{}w^aM copia{3'LTR}w^a59k1 copia{}w^a coral{}w^co Doc{}w¹ I{407}w^IR3 I{}w^aR84h I{}w^IR1 I{}w^IR2 I{}w^IR4 I{}w^IR5 I{}w^IR6 roo{}w^ric
Natural transposons (1)
	Transpac