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Reference Report
| Reference | |||
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| Citation | Lee, Y.J., Shah, S., Suzuki, E., Zars, T., O'Day, P.M., Hyde, D.R. (1994). The Drosophila dgq gene encodes a G<down></down> protein that mediates phototransduction. Neuron 13(5): 1143--1157. (Export to RIS) | ||
| FlyBase ID | FBrf0077001 | ||
| Publication Type | Research paper | ||
| PubMed ID | 7946351 | ||
| PubMed Abstract | We examined the roles of the Drosophila Gq alpha proteins (DGq) in the phototransduction pathway. The DGq proteins immunolocalized to the ocelli and all eight retinular photoreceptor cell rhabdomeres. An affinity-purified anti-DGq alpha immunoglobulin blocked the light-dependent GTP hydrolysis activity associated with Drosophila head membranes in vitro, suggesting that rhodopsin stimulated DGq. Dominantly active DGq1 mutants exhibited a light-independent GTPase activity and abnormal electrophysiological light responses, such as reduced retinal sensitivity and slow response kinetics compared with wild-type flies. Dominant DGq2 mutants exhibited a light-independent GTPase activity with normal electrophysiological light responses. Retinas of double mutants of DGq1, but not DGq2, with the light-dependent retinal degeneration mutant rdgB degenerated even in the dark. DGq1 stimulation of rdgB retinal degeneration in the dark was norpA-dependent. These results indicate that DGq1 mediates the stimulation by light-activated rhodopsin of the norpA-encoded phospholipase C in the visual transduction cascade. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Neuron | ||
| Title | Neuron | ||
| Publication Year | 1988- | ||
| ISBN/ISSN | 0896-6273 | ||
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Data from Reference
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| Aberrations (1)
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| Alleles (8)
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| Constructs (4)
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| Genes (7)
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