Reference Report

Reference
Citation	Lin, D.M., Goodman, C.S. (1994). Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 13(3): 507--523. (Export to RIS)
FlyBase ID	FBrf0077004
Publication Type	Research paper
PubMed ID	7917288
PubMed Abstract	We used the enhancer detection/GAL4 system in Drosophila to direct increased levels of Fasciclin II (Fas II) expression on motoneuron growth cones and axons and to direct ectopic Fas II expression on other cells they encounter. Four classes of abnormal phenotypes are observed: "bypass" phenotypes, in which axons fail to defasciculate at the choice point where they would normally enter their muscle target region and instead extend past their target; "detour" phenotypes, in which these bypass growth cones enter their muscle target region at a different location; "stall" phenotypes, in which axons that enter their muscle target region fail to defasciculate from one another to probe their muscle targets; and "misroute" phenotypes, in which growth cones are diverted onto abnormal pathways by contact with Fas II-positive cells. These phenotypes show that changes in the pattern and level of Fas II expression can alter growth cone guidance, apparently in part by modulating the ability of these growth cones to respond to other guidance cues.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	In(2LR)O
Alleles (8)
	Ecol\lacZ^Scer\UAS.cFa elav^C155 Fas2^e76 Fas2^Scer\UAS.cLa Scer\GAL4^C38 Scer\GAL4^elav-C155 Scer\GAL4^ftz.ng w^+mC
Balancers (1)
	CyO-β-actin
Constructs (5)
	P{GAL4-ftz.ng} P{UAS-Fas2.PEST-} P{UAS-lacZ.Hsp70} pP{GAL4-ftz.ng} pP{UAS-Fas2.PEST-}
Genes (5)
	Ecol\lacZ elav Fas2 Scer\GAL4 w
Insertions (2)
	P{GawB}C38 P{GawB}elav^C155