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Citation
Kunisch, M., Haenlin, M., Campos-Ortega, J.A. (1994). Lateral inhibition mediated by the Drosophila neurogenic gene Delta is enhanced by proneural proteins.  Proc. Natl. Acad. Sci. U.S.A. 91(21): 10139--10143.
FlyBase ID
FBrf0077244
Publication Type
Research paper
Abstract

Cells in the neuroectoderm of Drosophila become either neural or epidermal progenitors. A critical threshold concentration of proneural gene products in a given cell causes it to develop as a neuroblast. The proteins encoded by the genes Delta (Dl) and Notch (N) act as the source and the receptor, respectively, of inhibitory signals sent by the neuroblast to neighboring cells that prevent these cells from also adopting the neural fate. We show here that proneural gene products activate transcription of Delta in the neuroectoderm by binding to specific sites in its promoter. This transcriptional activation enhances lateral inhibition and thus helps ensure that cells in the vicinity of prospective neuroblasts will themselves become epidermoblasts.

PubMed ID
PubMed Central ID
PMC44973 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (2)
    Alleles (13)
    Genes (7)
    Sequence Features (4)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (10)