Reference Report

Reference
Citation	Carthew, R.W., Neufeld, T.P., Rubin, G.M. (1994). Identification of genes that interact with the sina gene in Drosophila eye development. Proc. Natl. Acad. Sci. U.S.A. 91(24): 11689--11693. (Export to RIS)
FlyBase ID	FBrf0077257
Publication Type	Research paper
External Crossreferences
PubMed ID	7972125
PubMed Abstract	The sina gene encodes a nuclear protein that is required for the correct development of R7 photoreceptor cells in the Drosophila eye. We conducted a genetic screen for mutations that reduce the activity of sina and found mutations that define nine genes whose products may be required for normal sina activity. Three of these genes also appear to be essential for signaling by the Sevenless-Ras pathway in R7 cells, of which one gene corresponds to the rolled locus (rl). The rl gene is known to encode a mitogen-activated protein kinase necessary for signaling by Ras. These results suggest that the products of these three genes may participate in a signaling pathway involving both Ras and Sina, possibly by functionally linking these two proteins.
BIOSIS ID	98048490
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Editors
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (1)
	Df(3R)E(sina)9
Alleles (19)
	E(sina)1^D1 E(sina)3^K1 E(sina)4^K5 E(sina)6^L3 E(sina)6^M4 E(sina)46C^M1 gl^ES5 Hsp83^H3 pnut^H2 Ras85D^V12.sev rl^10a rl^10b rl^ES7 Scer\FLP1^hs.PG sina⁴ sina^C2 sina^F1 sina^I1 sina^N6
Constructs (1)
	P{sevRas1.V12}
Genes (15)
	E(sina)1 E(sina)3 E(sina)4 E(sina)6 E(sina)46C faf gl God Hsp83 kni pnut Ras85D rl Scer\FLP1 sina