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Reference
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| Citation |
Raftery, L.A., Twombly, V., Wharton, K.A., Gelbart, W.M. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139(1): 241--254. |
| FlyBase ID |
FBrf0079237 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
7705627 |
| PubMed Abstract |
Pathways for regulation of signaling by transforming growth factor-beta family members are poorly understood at present. The
best genetically characterized member of this family is encoded by the Drosophila gene decapentaplegic (dpp), which is required
for multiple events during fly development. We describe here the results of screens for genes required to maximize dpp signaling
during embryonic dorsal-ventral patterning. Screens for genetic interactions in the zygote have identified an allele of tolloid,
as well as two novel alleles of screw, a gene recently shown to encode another bone morphogenetic protein-like polypeptide.
Both genes are required for patterning the dorsalmost tissues of the embryo. Screens for dpp interactions with maternally
expressed genes have identified loss of function mutations in Mothers against dpp and Medea. These mutations are homozygous
pupal lethal, engendering gut defects and severely reduced imaginal disks, reminiscent of dpp mutant phenotypes arising during
other dpp-dependent developmental events. Genetic interaction phenotypes are consistent with reduction of dpp activity in
the early embryo and in the imaginal disks. We propose that the novel screw mutations identified here titrate out some component(s)
of the dpp signaling pathway. We propose that Mad and Medea encode rate-limiting components integral to dpp pathways throughout
development.
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| Biosis |
98121680 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Genetics |
| Title |
Genetics |
| Authors |
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| Volume range |
1- |
| Year range |
1916- |
| Page range |
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| Publisher |
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| Place of publication |
Austin, TX, etc |
| Language of publication |
English |
| ISBN/ISSN |
0016-6731 |
| CODEN |
GENTAE |
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Data from Reference
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| Aberrations (7)
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| Alleles (37)
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| Balancers (1)
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| Constructs (1)
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| Genes (6)
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| Insertions (1)
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