|Citation||Tio, M., Ma, C., Moses, K. (1994). spitz, a Drosophila homolog of transforming growth factor-, is required in the founding photoreceptor cells of the compound eye facets. Mech. Dev. 48(1): 13--23. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Cell type specification and differentiation in the developing Drosophila compound eye begins in the morphogenetic furrow. In the furrow, cells are organized into evenly spaced preclusters and there is a synchronized arrest of the cells' mitotic cycle in G1. We report that recessive spitz loss-of-function mutations affect compound eye development. Spitz is homologous to the human transforming growth factor-alpha. In mosaic clones, spitz function is required in the first photoreceptor cells to differentiate for normal ommatidial development. spitz loss-of-function mutations are dominant suppressors of EgfrE gain-of-function mutations of the epidermal growth factor-receptor gene. These data suggest that the spitz product is a precluster promoting factor. spitz transcription increases abruptly in the morphogenetic furrow, the obverse of Egfr expression. We present a model for the expression of, and cellular requirement for, this growth factor homolog.|
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|Language of Publication||English|
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|Also Published As|
|Title||Mechanisms of Development|
|Data from Reference|