Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Tio, M., Ma, C., Moses, K. (1994). spitz, a Drosophila homolog of transforming growth factor-, is required in the founding photoreceptor cells of the compound eye facets. Mech. Dev. 48(1): 13--23. (Export to RIS) | ||
| FlyBase ID | FBrf0079521 | ||
| Publication Type | Research paper | ||
| PubMed ID | 7833285 | ||
| PubMed Abstract | Cell type specification and differentiation in the developing Drosophila compound eye begins in the morphogenetic furrow. In the furrow, cells are organized into evenly spaced preclusters and there is a synchronized arrest of the cells' mitotic cycle in G1. We report that recessive spitz loss-of-function mutations affect compound eye development. Spitz is homologous to the human transforming growth factor-alpha. In mosaic clones, spitz function is required in the first photoreceptor cells to differentiate for normal ommatidial development. spitz loss-of-function mutations are dominant suppressors of EgfrE gain-of-function mutations of the epidermal growth factor-receptor gene. These data suggest that the spitz product is a precluster promoting factor. spitz transcription increases abruptly in the morphogenetic furrow, the obverse of Egfr expression. We present a model for the expression of, and cellular requirement for, this growth factor homolog. | ||
| DOI | |||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Mech. Dev. | ||
| Title | Mechanisms of Development | ||
| Publication Year | 1990- | ||
| ISBN/ISSN | 0925-4773 | ||
|
Data from Reference
|
|||
| Aberrations (6)
|
|||
| Alleles (12)
|
|||
| Genes (6)
|
|||
| Insertions (2)
|
|||