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Citation
Brunner, A., Twardzik, T., Schneuwly, S. (1994). The Drosophila giant lens gene plays a dual role in eye and optic lobe development: Inhibition of differentiation of ommatidial cells and interference in photoreceptor axon guidance.  Mech. Dev. 48(3): 175--185.
FlyBase ID
FBrf0079912
Publication Type
Research paper
Abstract
The Drosophila giant lens (gil) gene encodes a secreted molecule which if absent leads to the recruitment of additional ommatidial cells normally eliminated by apoptosis. Heat induced ectopic gil expression leads to a reduction of ommatidial cells suggesting that gil is secreted by differentiating cells to prevent the development of an excess of cells of a given ommatidial cell type. A second important defect is the misrouting of photoreceptor axons in gil mutants. However, gil function is not required in photoreceptor axons for the establishment of proper connections. We propose that gil acts on the development of lamina cells preventing the correct differentiation of the target region of photoreceptor axons and therefore leading to an axon guidance phenotype.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference
    Aberrations (1)
    Alleles (10)
    Genes (5)
    Insertions (2)
    Transgenic Constructs (2)