Reference Report

Reference
Citation	Li, W., Ohlmeyer, J.T., Lane, M.E., Kalderon, D. (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80(4): 553--562. (Export to RIS)
FlyBase ID	FBrf0080213
Publication Type	Research paper
PubMed ID	7867063
PubMed Abstract	Reduced protein kinase A (PKA) activity in anterior imaginal disc cells leads to cell-autonomous induction of decapentaplegic (dpp), wingless (wg), and patched (ptc) transcription that is independent of hedgehog (hh) gene activity. The resulting nonautonomous adult wing and leg pattern duplications are largely due to induced dpp and wg expression and resemble phenotypes elicited by ectopic hh expression. Inhibition of PKA in anterior cells close to the posterior compartment can substitute for hh activity to promote growth of imaginal discs, whereas overexpression of PKA can counteract transcriptional induction of ptc by hh in these cells. PKA therefore appears to be an integral component of the mechanism by which hh regulates the expression of key patterning molecules in imaginal discs.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (32)
	dpp^H46 dpp^H61 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^en.A Ecol\lacZ^hh-P30 Ecol\lacZ^ptc.PS hh^ts2 Hsp70Ab^polyA Mmus\Pkaca^mC.Act5C Mmus\Pkaca^{mC.Scer\FRT.Act5C} Mmus\Pkaca^{mC.Scer\FRT.Scer\UAS} Mmus\Pkaca^mC.Scer\UAS Pka-C1^A13 Pka-C1^B3 Pka-C1^B10 Pka-C1^B12 Pka-C1^C2 Pka-C1^H2 Pka-C1^MB581 Pka-R1^BDK.Scer\UAS Pka-R1^BGD.Scer\UAS ptc^S2 ry^+t7.2 Scer\FLP1^hs.PG Scer\GAL4^C166-2 Scer\GAL4^E62-2 Scer\GAL4^h-1J3 w^+mC wg^en11 wg^L2 wg^l-17 y^+t7.7
Constructs (15)
	P{BS3.0} P{en1} P{hsFLP} P{PKA.mC.Act5C} P{PKA.mC.FRT} P{ptc-lacZ.S} P{UAS-PKA.mC.FRT} P{UAS-PKA.mC} P{UAS-Pka-R1.BDK} P{UAS-Pka-R1.BGD} pP{PKA.mC.FRT} pP{ptc-lacZ.S} pP{UAS-PKA.mC.FRT} pP{UAS-Pka-R1.BDK} pP{UAS-Pka-R1.BGD}
Genes (14)
	dpp Ecol\lacZ hh Hsp70Ab Mmus\Pkaca Pka-C1 Pka-R1 ptc ry Scer\FLP1 Scer\GAL4 w wg y
Insertions (5)
	P{en1}wg^en11 P{GawB}C166-2 P{GawB}E62-2 P{GawB}h^1J3 P{PZ}hh^P30