Reference Report

Reference
Citation	Martin, K.A., Poeck, B., Roth, H., Ebens, A.J., Ballard, L.C., Zipursky, S.L. (1995). Mutations disrupting neuronal connectivity in the Drosophila visual system. Neuron 14(2): 229--240. (Export to RIS)
FlyBase ID	FBrf0080232
Publication Type	Research paper
PubMed ID	7857635
PubMed Abstract	The photoreceptor neurons (R cells) of the Drosophila compound eye elaborate a precise array of neuronal connections in the brain. These projections exhibit target specificity and create topographic maps (retinotopy). We have screened histologically for mutations disrupting R cell connectivity in developing tissue. Eighty mutations were isolated from over 6000 ethylmethane sulfonate-mutagenized lines. Characterization of these mutations included genetic mosaic analysis to determine whether the gene is required in the retina or in the optic ganglia. Most mutations were found to affect connectivity indirectly by disrupting development more generally in the eye or brain. Genes were identified as candidates for playing direct roles in R cell connectivity by affecting axonal outgrowth (eddy), target recognition (limbo and nonstop), and retinotopy (limbo).
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (9)
	Df(1)KA10 Df(3L)Cat Df(3L)W4 Df(3L)W10 Dp(1;2;Y)w⁺ Dp(1;2)v⁺65b Dp(1;2)w⁺64b Tp(1;2)v⁺65b Tp(1;2)w⁺64b
Alleles (12)
	diva¹ diva² Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^gl-B172 Ecol\lacZ^lama-A8 Ecol\lacZ^LL13 Ecol\lacZ^loco-3-109 Ecol\lacZ^not-02069 eddy¹ limbo¹ not¹ not⁰²⁰⁶⁹
Constructs (1)
	P{BS3.0}
Genes (7)
	diva Ecol\lacZ eddy limbo not so st
Insertions (5)
	P{lacW}gl^B172 P{lacZ}LL13 P{lacZ}loco^3-109 P{PZ}A8 P{PZ}not⁰²⁰⁶⁹