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Citation
Pauli, D., Oliver, B., Mahowald, A.P. (1995). Identification of regions interacting with ovoD mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster.  Genetics 139(2): 713--732.
FlyBase ID
FBrf0080317
Publication Type
Research paper
Abstract
Only a few Drosophila melanogaster germline sex determination genes are known, and there have been no systematic screens to identify new genes involved in this important biological process. The ovarian phenotypes produced by females mutant for dominant alleles of the ovo gene are modified in flies with altered doses of other loci involved in germline sex determination in Drosophila (Sex-lethal+, sans fille+ and ovarian tumor+). This observation constitutes the basis for a screen to identify additional genes required for proper establishment of germline sexual identity. We tested 300 deletions, which together cover approximately 58% of the euchromatic portion of the genome, for genetic interactions with ovoD. Hemizygosity for more than a dozen small regions show interactions that either partially suppress or enhance the ovarian phenotypes of females mutant for one or more of the three dominant ovo mutations. These regions probably contain genes whose products act in developmental hierarchies that include ovo+ protein.
PubMed ID
PubMed Central ID
PMC1206376 (PMC) (EuropePMC)
DOI
Related Publication(s)
Research paper
Dose dependent enhancers and suppressors of ovoD2.
Pauli et al., 1995, D. I. S. 76: 107--124 [FBrf0082455]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
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    Alleles (4)
    Genes (12)