Reference Report

Reference
Citation	Colas, J.F., Launay, J.M., Kellermann, O., Rosay, P., Maroteaux, L. (1995). Drosophila 5-HT₂ serotonin receptor: coexpression with fushi-tarazu during segmentation. Proc. Natl. Acad. Sci. U.S.A. 92(12): 5441--5445. (Export to RIS)
FlyBase ID	FBrf0081644
Publication Type	Research paper
PubMed ID	7777527
PubMed Abstract	Serotonin, first described as a neurotransmitter in invertebrates, has been investigated mostly for its functions in the mature central nervous system of higher vertebrates. Serotonin receptor diversity has been described in the mammalian brain and in insects. We report the isolation of a cDNA coding for a Drosophila melanogaster serotonin receptor that displays a sequence, a gene organization, and pharmacological properties typical of the mammalian 5-HT2 serotonin receptor subtype. Its mRNA can be detected in the adult fly; moreover, a high level of expression occurs at 3 hr of Drosophila embryogenesis. This early embryonic expression is surprisingly organized in a seven-stripe pattern that appears at the cellular blastoderm stage. In addition, this pattern is in phase with that of the even-parasegment-expressed pair-rule gene fushi-tarazu and is similarly modified by mutations affecting segmentation genes. Simultaneously with this pair-rule expression, the complete machinery of serotonin synthesis is present and leads to a peak of ligand concomitant with a peak of 5-HT2-specific receptor sites in blastoderm embryos.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (3)
	Df(3R)6-7 Df(3R)110 Df(3R)p25
Alleles (12)
	en⁵⁴ eve³ ftz¹³ gt^YA82 h²⁵ hb¹ kni¹¹ Kr¹ odd⁵ run²⁸ sna¹⁸ tll¹
Genes (14)
	5-HT2 en eve ftz gt h hb kni Kr odd opa run sna tll