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Citation
Price, J.L. (1995). Are competing intermolecular and intramolecular interactions of PERIOD protein important for the regulation of circadian rhythms in Drosophila?  BioEssays 17(7): 583--586.
FlyBase ID
FBrf0083378
Publication Type
Review
Abstract

Genetic analysis is revealing molecular components of circadian rhythms. The gene products of the period gene in Drosophila and the frequency gene in Neurospora oscillate with a circadian rhythm. A recent paper (1) has shown that the PERIOD protein can undergo both intermolecular and intramolecular interactions in vitro. The effects of temperature and two period mutations on these molecular interactions were compared to the effects of the mutations and temperature on the in vivo period length of circadian rhythms. The results suggest that the molecular interactions may compete to maintain a rhythm with a constant period over a wide temperature range.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BioEssays
    Title
    BioEssays
    Publication Year
    1984-
    ISBN/ISSN
    0265-9247
    Data From Reference
    Alleles (3)
    Genes (3)