Reference Report

Reference
Citation	Salzberg, A., D'Evelyn, D., Schulze, K.L., Lee, J.K., Strumpf, D., Tsai, L., Bellen, H.J. (1994). Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13(2): 269--287. (Export to RIS)
FlyBase ID	FBrf0083410
Publication Type	Research paper
PubMed ID	8060613
PubMed Abstract	Through a systematic genetic screen, we have identified 55 mutations that affect the development of the PNS of Drosophila embryos. These mutations specify 13 novel and 5 previously characterized genes and define new phenotypes for 2 other known genes. Five classes of mutant phenotypes were identified in the screen: gain of neurons, loss of neurons, abnormal position of chordotonal neurons, aberrant neuronal trajectories, and abnormal morphology of neurons. Phenotypic analyses of mutations identified in this study revealed three novel aspects of PNS development. First, we have identified a novel gene that may be required to define glial versus neuronal cell identity. Second, our data indicate that neuronal migration plays an important role in pattern formation in the embryonic PNS. Third, we have identified mutations that cause a lack of sensory organs, but unlike mutations in proneural genes, do not affect the formation of sensory organ precursors. These genes may be required for key aspects of neuronal differentiation. Our studies suggest that approximately 70 essential genes are required for proper PNS development in Drosophila embryos.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (16)
	Df(3L)ems13 Df(3L)GN19 Df(3L)S122804 Df(3L)TE1 Df(3L)XDI98 Df(3R)Antp17 Df(3R)awd-KRB Df(3R)by10 Df(3R)by416 Df(3R)CA1 Df(3R)dsx10M Df(3R)dsx11 Df(3R)dsx29 Df(3R)p13 Df(3R)p-XT103 Df(3R)tll-g
Alleles (60)
	abd-A^K397 abd-A^K622 CycA⁵ CycA^H170 CycA^L90 ded^G371 ded^I26 Dl^D381 Dl^F362 Dl^H376 Dl^J147 dmt^I184 dmt^I265 dmt^M288 dmt^M572 Ecol\lacZ^bft-E8-2-46 Ecol\lacZ^Hsp83-08445 hth^dtl-H321 hth^dtl-J186 hth^dtl-S132307b misn^E95 misn^K243 misn^L201 misn^M65 misn^M176 neur^F123 neur^F180 neur^G370 neur^K437 pav^A375 pav^B200 pav^D295 pav^L157 pav^M187 pav^M547 pros^C82 pros^D135 pros^E67 pros^G421 pros^J76 pros^K816 puc^H246 rho^L68 sens^I235 sens^M256 sens^M608 spdo^C55 spdo^K433 stich1^D233 stich2^D337 tgo^F261 tgo^J68 ttk^1e11 ttk^B330 ttk^E389 vvl^H76 vvl^H599 vvl^M638 wan^J368 wan^K835
Genes (31)
	abd-A ato cpo ct CycA da ded Dl dmt E(spl)m8-HLH Ecol\lacZ hth misn neur nrm numb pav pnt pros puc rho sens spdo stich1 stich2 tgo trh ttk vvl wan wg
Insertions (2)
	P{lacW}E8-2-46 P{PZ}Hsp83⁰⁸⁴⁴⁵