Reference Report

Reference
Citation	Schweitzer, R., Howes, R., Smith, R., Shilo, B.Z., Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376(6542): 699--702. (Export to RIS)
FlyBase ID	FBrf0083425
Publication Type	Research paper
PubMed ID	7651519
PubMed Abstract	The Drosophila homologue of the mammalian epidermal growth factor (EGF) receptor (DER) is a receptor tyrosine kinase involved in many stages of fly development, including photoreceptor determination, and wing-vein formation. Its primary activating ligand is the Spitz protein, which is similar to mammalian TGF-alpha. Argos is a secreted protein that, like Spitz, contains a single EGF motif. It is a repressor of cell determination in the eye, and acts in other tissues, including the wing. Because Argos has the opposite effects to DER in the eye (the former blocks photoreceptor determination, the latter promotes it) we have tested whether it acts by blocking the DER pathway. We show that Argos does indeed repress this pathway in vivo and find that, in vitro, Argos protein can inhibit the activation of DER by Spitz. Thus the determination of cells by the DER pathway is regulated by a balance between extracellular activating and inhibiting signals. This is the first in vivo example of an extracellular inhibitor of a receptor tyrosine kinase.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (37)
	aos^A254Δ33 aos^hs.PF aos^T:Zzzz\His6 aos^Δ7 aos^Δ9 drk^e0A Egfr^2.MtnA Egfr^E1 Egfr^E3 Egfr^f1 Egfr^f2 Egfr^f3 Egfr^f6 Egfr^f7 Egfr^f8 Egfr^f9 Egfr^flb-2E07 Egfr^top-101 Egfr^WT.hs phl¹¹ phl¹² Ras85D^e1B Ras85D^e2F RasGAP1^B2 RasGAP1^S16 rho^PΔ5 rl¹ rl^10a rl²⁶ S²¹⁸ S⁰⁵⁶⁷¹ Sos^e0D Sos^e2H spi¹ spi² spi³ spi^s.MtnA
Constructs (2)
	P{HS-argos.F} P{hs-Egfr.wt}
Genes (12)
	aos drk Egfr phl Ras85D RasGAP1 rho rl S Sos spi T:Zzzz\His6