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Reference
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| Citation |
Bashaw, G.J., Baker, B.S. (1995). The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically
regulated by Sex-lethal. Development 121(10): 3245--3258. |
| FlyBase ID |
FBrf0083765 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
7588059 |
| PubMed Abstract |
In Drosophila dosage compensation increases the rate of transcription of the male's X chromosome and depends on four autosomal
male-specific lethal genes. We have cloned the msl-2 gene and shown that MSL-2 protein is co-localized with the other three
MSL proteins at hundreds of sites along the male polytene X chromosome and that this binding requires the other three MSL
proteins. msl-2 encodes a protein with a putative DNA-binding domain: the RING finger. MSL-2 protein is not produced in females
and sequences in both the 5' and 3' UTRs are important for this sex-specific regulation. Furthermore, msl-2 pre-mRNA is alternatively
spliced in a Sex-lethal-dependent fashion in its 5' UTR.
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| Biosis |
98548771 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Development |
| Title |
Development |
| Authors |
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| Volume range |
99- |
| Year range |
1987- |
| Page range |
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| Publisher |
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| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
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Data from Reference
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| Aberrations (20)
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| Alleles (7)
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| Constructs (4)
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| Genes (12)
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| Natural transposons (1)
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