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Citation
Hosoya, T., Takizawa, K., Nitta, K., Hotta, Y. (1995). glial cells missing: a binary switch between neuronal and glial determination in Drosophila.  Cell 82(6): 1025--1036.
FlyBase ID
FBrf0084044
Publication Type
Research paper
Abstract

In the Drosophila CNS, both neurons and glial are derived from neuroblasts. We have identified a gene, glial cells missing (gcm), that encodes a novel nuclear protein expressed transiently in early glial cells. Its mutation causes presumptive glial cells to differentiate into neurons, whereas its ectopic expression forces virtually all CNS cells to become glial cells. Thus, gcm functions as a binary switch that turns on glial fate while inhibiting default neuronal fate of the neuroblasts and their progeny. Similar results are also obtained in the PNS. Analyses of the mutant revealed that "pioneer neurons" can find correct pathways without glial cells and that neurons and glia have a common molecular basis for individual identity.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (8)
    Genes (7)
    Molecular Constructs (1)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (1)