Reference Report

Reference
Citation	Hu, X., Lee, E.C., Baker, N.E. (1995). Molecular analysis of scabrous mutant alleles from Drosophila melanogaster indicates a secreted protein with two functional domains. Genetics 141(2): 607--617. (Export to RIS)
FlyBase ID	FBrf0084048
Publication Type	Research paper
PubMed ID	8647397
PubMed Abstract	Mutations at the scabrous locus (sca) affect cell-cell signaling during neural development. Twenty-one mutant alleles of scabrous have been analyzed. Many synthesize no sca protein. In others, a defective protein is arrested intracellularly. Two mutants in which protein is not arrested must affect sca protein function outside the cell. Both affect the fibrinogen related domain (FReD), a 200-amino acid segment conserved in fibrinogen, tenascins, and other proteins. In fibrinogen, this region is involved in protein interactions and is altered in human mutations affecting blood clotting. In sca(UM2), an invariant Asp residue is replaced by Asn. In sca(MSKF) allele has dominant negative properties, indicating that the truncated amino-terminal portion interferes with the function of so me other gene product. These mutations show that the conserved FReD is essential for wild-type sca function, but suggest that the amino-terminal domain also interacts with other proteins, but other neural mutations were without effect. Models for the role of a two-domain protein in neural development are discussed.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(1)N-54l9 Df(2R)CX1 Df(2R)sca-KX2 Df(2R)vg-D Df(3R)Espl1 Dp(1;1)Co Dp(3;1)O5 In(2R)sca^BX1 Tp(3;1)O5
Alleles (29)
	bib¹ Dl^9P mam⁸ N^spl-1 neur¹ sca¹ sca² sca^88-1 sca^88-2 sca^88-3 sca^B1 sca^BP1 sca^BP2 sca^BP3 sca^BX1 sca^KE3 sca^KE15 sca^KE17 sca^KE305 sca^KX2 sca^MSKF.cHa sca^MSKF sca^OB7 sca^TM4 sca^UM2 sca^WB1 sca^XL1 sgg³² Su(spl)^KE7
Genes (9)
	bib Dl E(spl)m8-HLH mam N neur sca sgg Su(spl)
Insertions (2)
	H{}sca^MSKF P{}sca^BP1