Reference Report

Reference
Citation	Brand, A.H., Dormand, E.L. (1995). The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system. Curr. Opin. Neurobiol. 5(5): 572--578. (Export to RIS)
FlyBase ID	FBrf0084801
Publication Type	Review
PubMed ID	8580708
PubMed Abstract	The GAL4 system is a method for directed gene expression that allows genes to be expressed ectopically in numerous cell- or tissue-specific patterns. The technique is being exploited to study the Drosophila melanogaster nervous system at all stages of development, from the embryo to the adult. The GAL4 system is being used to target the expression of novel marker genes in living animals to label cells, or subcellular structures. Directed expression of toxin genes can be used as a method for targeted cell ablation to study the role of cell-cell interactions in development. Ectopic expression helps to elucidate the function of different genes in cell fate determination and differentiation, and is helping to define the regions of the brain involved in sexual behaviour.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Opin. Neurobiol.
Title	Current Opinion in Neurobiology
Publication Year	1991-
ISBN/ISSN	0959-4388
Data from Reference
Alleles (21)
	aop^Scer\UAS.cRa ase^Scer\UAS.cBa Avic\GFP^Scer\UAS.cYa Avic\GFP^{Scer\UAS.T:Btau\MAPT} Ctet\TeTxLC^TNT.Scer\UAS E(spl)m8-HLH^Scer\UAS.cTa Ecol\lacZ^P\T.A92 Ecol\lacZ^Scer\UAS.cBa Ecol\lacZ^{Scer\UAS.T:Btau\MAPT} ey^Scer\UAS.cHa Fas2^Scer\UAS.cLa l(1)sc^Scer\UAS.cHa Mmus\Pax6^Scer\UAS.cHa pnt^P1.Scer\UAS pnt^P2.Scer\UAS Rac1^Scer\UAS.cLa Rnor\CD2^{Scer\UAS.cDBa} Scer\GAL4^Adh.PF Ser^Scer\UAS.cGa tra^Scer\UAS.cFa w^+mC
Constructs (20)
	P{A92} P{GAL4-Adh.Dmul} P{UAS-aop.WT} P{UAS-ase.B} P{UAS-CD2} P{UAS-E(spl).T} P{UAS-ey.H} P{UAS-Fas2.PEST-} P{UAS-GFP.btau} P{UAS-GFP.Y} P{UAS-l(1)sc.LSC} P{UAS-lacZ.B} P{UAS-Pax-6.mus} P{UAS-pnt.P1} P{UAS-pnt.P2} P{UAS-Rac1.L} P{UAS-Ser.G} P{UAS-tau-lacZ.B} P{UAS-TeTxLC.tnt} P{UAS-tra.F}
Genes (19)
	aop ase Avic\GFP Btau\MAPT Ctet\TeTxLC E(spl)m8-HLH Ecol\lacZ ey Fas2 l(1)sc Mmus\Pax6 pnt Rac1 Rnor\CD2 Scer\GAL4 Ser T:Btau\MAPT tra w