Reference Report

Reference
Citation	Feger, G., Vassin, H., Su, T.T., Wolff, E., Jan, L.Y., Jan, Y.N. (1995). dpa, A member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. EMBO J. 14(21): 5387--5398. (Export to RIS)
FlyBase ID	FBrf0085022
Publication Type	Research paper
PubMed ID	7489728
PubMed Abstract	We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA replication defects in mitotically proliferating cells. In contrast, dpa is dispensable for endoreplication, a specialized cell cycle consisting of consecutive rounds of S phases without intervening mitosis. Our studies suggest an essential role for dpa in mitotic DNA replication but not in endoreplication. Thus, dpa is not a general replication factor but may play a specialized regulatory role in DNA replication.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Aberrations (3)
	Df(2R)R163 Df(2R)ST1 T(2;3)H36
Alleles (8)
	dpa¹ dpa^+t12 dpa^H36 Ecol\lacZ^dpa-E5-2-23 l(2)43Cb¹ l(2)43Cc¹ l(2)43Da² w^+mC
Constructs (1)
	P{dpa⁺12}
Genes (8)
	dpa Ecol\lacZ esg l(2)43Cb l(2)43Cc l(2)43Da sna w
Insertions (1)
	P{lacW}E5-2-23