Reference Report

Reference
Citation	Brodsky, M.H., Steller, H. (1996). Positional information along the dorsal-ventral axis of the Drosophila eye: Graded expression of the four-jointed gene. Dev. Biol. 173(2): 428--446. (Export to RIS)
FlyBase ID	FBrf0086339
Publication Type	Research paper
PubMed ID	8606003
PubMed Abstract	Several observations suggest that developing ommatidia in the Drosophila eye have distinct dorsal-ventral (d-v) positional identities, despite their morphological uniformity. To identify molecular differences along the d-v axis of the eye, we carried out a systematic screen for P-element insertions that show nonuniform reporter gene expression along this axis. We identified P-element insertions in which lacZ expression is activated in dorsal, ventral, or equatorial regions of the disc. These patterns of transcriptional enhancer activity are established early in disc development and are maintained in a size invariant manner during disc growth. Several insertions with an equatorial-to-polar gradient of lacZ expression disrupt the four-jointed (fj) gene which is required for proper leg, wing, and eye development. The fj cDNA sequence includes a presumptive internal signal sequence, indicating that fj encodes a cell surface or secreted protein. Analysis of the fj phenotype and expression pattern in the leg suggests that fj is required for cell-cell signaling during disc development.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(2R)PC4
Alleles (36)
	Ecol\lacZ^fj-p1 Ecol\lacZ^fj-p2 Ecol\lacZ^fj-p3 Ecol\lacZ^fj-p4 Ecol\lacZ^fj-p5 Ecol\lacZ^fj-p6 Ecol\lacZ^fj-P55Cg4 Ecol\lacZ^fj-P55Ci10 Ecol\lacZ^fj-P55Ci20 Ecol\lacZ^mirr-P69Df7 Ecol\lacZ^P24De13 Ecol\lacZ^P53Cm100 fj¹ fj^d1 fj^d2 fj^d3 fj^p1 fj^p2 fj^p3 fj^p4 fj^p5 fj^p6 mirr^P69Df7 w^+mC w^fj-p1 w^fj-p2 w^fj-p3 w^fj-p4 w^fj-p5 w^fj-p6 w^fj-P55Cg4 w^fj-P55Ci10 w^fj-P55Ci20 w^P24De13 w^P53Cm100 w^P69Df7
Constructs (1)
	P{lacW}
Genes (4)
	Ecol\lacZ fj mirr w
Insertions (12)
	P{lacW}fj^p1 P{lacW}fj^p2 P{lacW}fj^p3 P{lacW}fj^p4 P{lacW}fj^p5 P{lacW}fj^p6 P{lacW}mirr^P69Df7 P{lacW}P24De13 P{lacW}P53Cm100 P{lacW}P55Cg4 P{lacW}P55Ci10 P{lacW}P55Ci20