Reference Report

Reference
Citation	Desai, C.J., Gindhart, J.G., Goldstein, L.S.B., Zinn, K. (1996). Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84(4): 599--609. (Export to RIS)
FlyBase ID	FBrf0086377
Publication Type	Research paper
PubMed ID	8598046
PubMed Abstract	The receptor tyrosine phosphatases DPTP69D and DPTP99A are expressed on motor axons in Drosophila embryos. In mutant embryos lacking DPTP69D protein, motor neuron growth cones stop growing before reaching their muscle targets, or follow incorrect pathways that bypass these muscles. Mutant embryos lacking DPTP99A are indistinguishable from wild type. Motor axon defects in dptp69D dptp99A double mutant embryos, however, are much more severe than in embryos lacking only DPTP69D. Our results demonstrate that DPTP69D and DPTP99A are required for motor axon guidance and that they have partially redundant functions during development of the neuro-muscular system.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	Df(3L)8ex25 Df(3L)8ex34 Df(3R)Ptp99A^R3
Alleles (13)
	Klc^8ex25 Klc^59A mirr^cre2 Ptp69D¹ Ptp69D² Ptp69D³ Ptp69D^8ex25 Ptp69D^11f3 Ptp69D^+t10.5 Ptp69D^unspecified Ptp99A¹ Ptp99A^R3 w^+mC
Constructs (1)
	P{dptp69D}
Genes (6)
	Klc mirr Ptp69D Ptp99A SmD1 w
Insertions (3)
	P{lacW}Klc^59A P{lacW}mirr^cre2 P{lacW}Ptp69D^11f3