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Citation	Francis-Lang, H., Davis, I., Ish-Horowicz, D. (1996). Asymmetric localization of Drosophila pair-rule transcripts from displaced nuclei: Evidence for directional nuclear export. EMBO J. 15(3): 640--649.
FlyBase ID	FBrf0086407
Type of publication	Research paper
Offprint Available	No
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PubMed ID	8599947
PubMed Abstract	Drosophila pair-rule transcripts accumulate exclusively apical of the layer of peripheral nuclei in syncytial blastoderm stage embryos. Here, we use aneuploid embryos to test zygotic gene requirements for pair-rule transcript localization. As apical localization is maintained in all genotypes tested, the required components must be maternally encoded. In aneuploid embryos with multiple layers or cortical nuclei, pair-rule transcripts lie apical of both superficial and internalized nuclei. In the latter case, the transcripts are 'pseudo-apical', i.e. apical of the nuclei from which they derive, but basal of superficial nuclei. We show that internalized nuclei maintain their apico-basal nuclear orientation, and that they lack the apical cytoskeletal assemblies which lie adjacent to superficial nuclei. These results support a mechanism of localizing pair-rule transcripts by directional (vectorial) nuclear export.
Biosis	98695155
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Language of publication	English
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Abbreviation	EMBO J.
Title	The EMBO Journal
Authors
Volume range	1-
Year range	1982-
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Place of publication	Oxford
Language of publication	English
ISBN/ISSN	0261-4189
CODEN	EMJODG
Data from Reference
Aberrations (4)
	C(1)M3 C(2)v C(3L)st C(3R)e
Genes (12)
	Kr Sry-α bnk eve ftz gt h hb kni nullo run tll