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Citation
Gomez-Skarmeta, J.L., Diez del Corral, R., De La Calle-Mustienes, E., Ferres-Marco, D., Modolell, J. (1996). Araucan and caupolican, two members of the novel Iroquois complex, encode homeoproteins that control proneural and vein-forming genes.  Cell 85(1): 95--105.
FlyBase ID
FBrf0086419
Publication Type
Research paper
Abstract

In Drosophila imaginal wing discs, the achaete-scute (ac-sc) proneural genes and rhomboid (veinlet) are expressed in highly resolved patterns that prefigure the positions of sensory organs and wing veins, respectively. It is thought that these patterns are generated by a combination of factors (a prepattern) regulating these genes. We provide evidence for the existence of this prepattern by identifying two of its factors, Araucan and Caupolican. They are members of a novel family of homeoproteins, with homologs in vertebrates. Araucan and Caupolican, present in domains of the imaginal discs larger than those expressing ac-sc and rhomboid, are necessary for expression of these genes in the overlapping domains. Araucan and Caupolican appear to be positive, direct regulators of ac-sc.

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Related Publication(s)
Review

Monitor.
Anonymous, 1996, Trends Genet. 12(8): 292 [FBrf0089986]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (5)
    Alleles (15)
    Genes (10)
    Sequence Features (2)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (1)