Reference Report

Reference
Citation	Hyduk, D., Percival-Smith, A. (1996). Genetic characterization of the homeodomain-independent activity of the Drosophila fushi tarazu gene product. Genetics 142(2): 481--492. (Export to RIS)
FlyBase ID	FBrf0086468
Publication Type	Research paper
PubMed ID	8852847
PubMed Abstract	The gene product of fushi tarazu (FTZ) has a homeodomain (HD)-independent activity. Ectopic expression of a FTZ protein that lacks half the HD in embryos results in the anti-ftz phenotype. We have characterized this FTZ HD-independent activity further. Ectopic expression of the HD-independent FTZ activity, in the absence of FTZ activity expressed from the endogenous ftz gene, was sufficient to result in the anti-ftz phenotype. Since the anti-ftz phenotype is a first instar larvae composed nearly entirely of FTZ-dependent cuticular structures derived from the even-numbered parasegments, this result suggests that expression of the HD-independent FTZ activity is sufficient to establish FTZ-dependent cuticle. Activation of FTZ-dependent Engrailed (EN) expression and activation of the ftz enhancer were HD-independent. The ftz enhancer element, AE-1, was activated by the HD-independent FTZ activity; however, the ftz enhancer element, AE-BS2CCC, which is the same as AE-1 except for the inactivation of two FTZ HD DNA-binding sites, was not. Activation of the ftz enhancer by ectopic expression of FTZ activity was effective only during gastrulation and germ band extension. In the discussion, we propose an explanation for these results.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	In(2LR)O In(3LR)TM3 In(3LR)TM6B
Alleles (10)
	Ecol\lacZ^ftz.AE Ecol\lacZ^ftz.AEBS2CCC Ecol\lacZ^ftz.UPHZ50H Ecol\lacZ^hb.P8 ftz^3-413.hs ftz¹¹ ftz¹³ ftz^223-413.hs ftz^Δ274-302.hs y^+t7.7
Balancers (6)
	CyO CyO-Thb8 TM3-SbSer TM3-Thb8 TM6B TM6B-vHa
Constructs (7)
	P{ftz.AE-1} P{ftz.AE-BS2CCC} P{ftz^Δ274-302} P{HSftz^3-413} P{HSftz^223-413} P{Thb8-lacZ} P{UPHZ50H}
Genes (3)
	Ecol\lacZ ftz y
Insertions (3)
	P{Thb8-lacZ}DM1 P{Thb8-lacZ}WD1 P{walLy}DH1