Reference Report

Reference
Citation	Bhadra, U., Birchler, J.A. (1996). Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila. Mol. Gen. Genet. 250(5): 601--613. (Export to RIS)
FlyBase ID	FBrf0086910
Publication Type	Research paper
PubMed ID	8676863
PubMed Abstract	Modifier of white (Mow), a dominant transacting gene, has been identified through a mutagenic screen for second-site loci that alter the level of expression of the white eye color locus. Mow reduces the expression of white in most developmental stages, but enhances its expression in the pupal stage, the time at which the major contribution to the adult phenotype is made. Tests with an Alcohol dehydrogenase promoter-white reporter and a series of white truncation constructs have shown that Mow fails to affect the reporter; cis-regulatory mutations of white also show no response, suggesting a requirement for white regulatory domains for interaction with Mow. A quantitative analysis of steady-state transcript levels reveals that the white mRNA level decreases in the presence of one dose of Mow in larvae and adults, but the reduction is greater in females than males. Two other functionally related genes, brown and scarlet, also exhibit a similar sexually dimorphic alteration in expression, mediated by Mow. In the mid-pupal stage, by contrast, the level of white and brown mRNA is increased by Mow. In addition, Mow acts as a weak suppressor of position effect variegation (PEV). These observations suggest a connection between dosage modulation of gene expression and suppression of position-effect variegation.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (12)
	Df(3R)Antp17 Df(3R)by10 Df(3R)by62 Df(3R)M-Kx1 Df(3R)p712 Df(3R)p-XT103 Df(3R)ry615 Df(3R)Scr Df(3R)T-32 In(1)w^m4h In(1)y^3P Tp(3;2)by62
Alleles (46)
	Mow^EMS Mow^gamma w¹ w^-113 w^+mF w^+mSC w^a2 w^a3 w^a4 w^a59k1 w^a w^aM w^apl w^aR84h w^bf2 w^bf w^BgB+173 w^bl w^Bwx w^c w^cf w^co w^col w^e w^E w^ec3 w^h wⁱ w^IR1 w^IR2 w^IR3 w^IR4 w^IR5 w^IR6 w^is w^mo w^ric w^sat w^sp1 w^sp2 w^sp3 w^sp4 w^sp55 w^sp81d w^t w^Z4-17
Constructs (6)
	P{(-113)miniW} P{BgB-(+173)miniW} P{miniW} P{wE} P{wF} P{Z4(-17)miniW}
Genes (6)
	bw Mow st w y z
Insertions (18)
	3S18{}w^a4 ?{}w^aM blood{}w^bl copia{3'LTR}w^a59k1 copia{}w^a coral{}w^co Doc{}w¹ I{407}w^IR3 I{}w^aR84h I{}w^IR1 I{}w^IR4 I{}w^IR5 I{}w^IR6 mdg3{}w^sp55 roo{}w^bf roo{}w^h roo{}w^ric roo{}w^sp1
Natural transposons (1)
	copia