Reference Report

Reference
Citation	Nellen, D., Burke, R., Struhl, G., Basler, K. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85(3): 357--368. (Export to RIS)
FlyBase ID	FBrf0087626
Publication Type	Research paper
PubMed ID	8616891
PubMed Abstract	During development of the Drosophila wing, the decapentaplegic (dpp) gene is expressed in a stripe of cells along the anteroposterior compartment boundary and gives rise to a secreted protein that exerts a long-range organizing influence on both compartments. Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on responding cells, rather than by proxy through the short-range induction of other signaling molecules. Further, we show that two genes, optomotor-blind and spalt are transcriptionally activated at different distances from DPP-secreting cells and provide evidence that these genes respond to different threshold concentrations of DPP protein. We propose that DPP acts as a gradient morphogen during wing development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (27)
	bi^X35 dpp^H61 dpp^{Scer\FRT.Rnor\CD2.αTub84B} dpp^{Scer\FRT.Scer\UAS} dpp^Scer\UAS.cNa dpp^Scer\UAS.cSa dpp^αTub84B.PN Ecol\lacZ^bi-X35 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^{salm-A405.1M2} Hsp70Ab^polyA put::tor^Scer\UAS.cNa put^Scer\UAS.cNa Rnor\CD2^A902 Scer\FLP1^hs.PG Scer\GAL4^69B Scer\GAL4^C-765 Scer\GAL4^dpp.blk1 Scer\GAL4^hs.2sev tkv::tor^Scer\UAS.cNa tkv^{Q253D.Scer\FRT.Scer\UAS} tkv^{Q253D.Scer\UAS.cNb} tkv^{Q253D.Scer\UAS.cNc} tkv^Scer\UAS.cNa tor^13D w^+mC y^+t7.7
Constructs (25)
	P{BS3.0} P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{hsFLP} P{UAS(FRT.y⁺CD2)dpp.N} P{UAS(FRT.y⁺CD2)tkv.Q253D.Nc} P{UAS(-FRT)dpp.N} P{UAS(-FRT)tkv.Q253D.Nc} P{UAS-dpp.S} P{UAS-put.N} P{UAS-put.tor.N} P{UAS-tkv.Na} P{UAS-tkv.Q253D.Nb} P{UAS-tkv.tor.N} P{αTub84B(FRT.y⁺CD2)dpp.N} P{αTub84B(-FRT)dpp.N} P{πM} pP{UAS-dpp.FRT.N} pP{UAS-put.N} pP{UAS-put.tor.N} pP{UAS-tkv.Na} pP{UAS-tkv.Q253D.FRT} pP{UAS-tkv.Q253D.Nb} pP{UAS-tkv.tor.N} pP{αTub84B(FRT.y⁺CD2)dpp.N}
Genes (16)
	bi dpp Ecol\lacZ Hsp70Ab put put::tor Rnor\CD2 salm Scer\FLP1 Scer\GAL4 tkv tkv::tor tor w y αTub84B
Insertions (4)
	P{GawB}69B P{GawB}C-765 P{lacW}bi^X35 P{lArB}salm^A405.1M2